Scikit Bio
ListedScikit Bio analyzes biological sequences (DNA, RNA, protein) using scikit-learn for pattern recognition and prediction – useful for bioinformatics research.
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terminal$ npx skills add davila7/claude-code-templates --skill scikit-bio -a claude-code Uses the open-source
skillsCLI and needs Node.js. Add-gto install it for your user instead of this project.
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davila7
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About this skill
What it does
The Scikit Bio skill enables AI agents to analyze biological data using the scikit-bio Python library. It facilitates tasks such as manipulating DNA, RNA, and protein sequences; reading and writing various biological file formats (FASTA, FASTQ, GenBank); performing sequence alignments; constructing phylogenetic trees; and calculating diversity metrics for microbiome or community ecology data. This skill is particularly useful for bioinformatics research requiring pattern recognition and prediction within biological datasets.
When to use it
- You need to read and process biological sequences from files in formats like FASTA or FASTQ.
- You're performing sequence alignment or searching for specific motifs within DNA, RNA, or protein data.
- You want to construct or analyze phylogenetic trees representing evolutionary relationships.
- You are calculating diversity metrics (alpha/beta diversity, UniFrac distances) from microbiome data.
Key capabilities
- Sequence Manipulation: Reading, writing, slicing, concatenating, and searching biological sequences (DNA, RNA, protein).
- File Format Support: Handles FASTA, FASTQ, GenBank, Newick, BIOM formats for reading and writing biological data.
- Sequence Transformations: Performs reverse complement, transcription (DNA→RNA), and translation (RNA→protein) operations.
- Motif Finding: Identifies specific patterns within sequences using regular expressions.
- Distance Calculations: Calculates distances between sequences (e.g., Hamming distance, k-mer based).
- Metadata Handling: Manages sequence quality scores and associated metadata.
Example prompts
- "Read the DNA sequence from 'my_sequence.fasta' and find all occurrences of the motif 'ATG'."
- "Translate the RNA sequence in 'rna_data.txt' into a protein sequence."
- "Calculate the Hamming distance between these two DNA sequences: [Sequence 1] and [Sequence 2]."
Tips & gotchas
- Use the
DNA,RNA, orProteinclasses when working with sequences that require specific alphabet validation. - The
Sequenceclass is suitable for generic sequences without alphabet restrictions. - Quality scores from FASTQ files are automatically loaded into positional metadata, which can be leveraged in subsequent analyses.