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Scikit Bio

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davila7·vlatest·ai-ml·MIT

Scikit Bio analyzes biological sequences (DNA, RNA, protein) using scikit-learn for pattern recognition and prediction – useful for bioinformatics research.

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  1. 1

    Run this in your project

    terminal
    $ npx skills add davila7/claude-code-templates --skill scikit-bio -a claude-code
  2. Uses the open-source skills CLI and needs Node.js. Add -g to install it for your user instead of this project.

What we know about this skill

Publisher

davila7

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About this skill

What it does

The Scikit Bio skill enables AI agents to analyze biological data using the scikit-bio Python library. It facilitates tasks such as manipulating DNA, RNA, and protein sequences; reading and writing various biological file formats (FASTA, FASTQ, GenBank); performing sequence alignments; constructing phylogenetic trees; and calculating diversity metrics for microbiome or community ecology data. This skill is particularly useful for bioinformatics research requiring pattern recognition and prediction within biological datasets.

When to use it

  • You need to read and process biological sequences from files in formats like FASTA or FASTQ.
  • You're performing sequence alignment or searching for specific motifs within DNA, RNA, or protein data.
  • You want to construct or analyze phylogenetic trees representing evolutionary relationships.
  • You are calculating diversity metrics (alpha/beta diversity, UniFrac distances) from microbiome data.

Key capabilities

  • Sequence Manipulation: Reading, writing, slicing, concatenating, and searching biological sequences (DNA, RNA, protein).
  • File Format Support: Handles FASTA, FASTQ, GenBank, Newick, BIOM formats for reading and writing biological data.
  • Sequence Transformations: Performs reverse complement, transcription (DNA→RNA), and translation (RNA→protein) operations.
  • Motif Finding: Identifies specific patterns within sequences using regular expressions.
  • Distance Calculations: Calculates distances between sequences (e.g., Hamming distance, k-mer based).
  • Metadata Handling: Manages sequence quality scores and associated metadata.

Example prompts

  • "Read the DNA sequence from 'my_sequence.fasta' and find all occurrences of the motif 'ATG'."
  • "Translate the RNA sequence in 'rna_data.txt' into a protein sequence."
  • "Calculate the Hamming distance between these two DNA sequences: [Sequence 1] and [Sequence 2]."

Tips & gotchas

  • Use the DNA, RNA, or Protein classes when working with sequences that require specific alphabet validation.
  • The Sequence class is suitable for generic sequences without alphabet restrictions.
  • Quality scores from FASTQ files are automatically loaded into positional metadata, which can be leveraged in subsequent analyses.